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DISEASE-MODIFYING THERAPY
Tysabri (natalizumab) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with relapsing forms of multiple sclerosis.
These insights are based on 14,205 comments about Tysabri from MyMSTeam members. These are the experiences of a small number of people and are not meant to be medical advice.
Tysabri is an integrin receptor agonist that works by blocking certain immune cells from sticking to blood vessel walls and moving into the brain and spinal cord. This change may lower the number of active immune cells that reach areas of inflammation. In multiple sclerosis, these immune cells can damage the protective covering of nerves. By slowing their movement, Tysabri may help reduce this inflammation. The exact way it works is not fully known.
Doctors prescribe Tysabri for adults with relapsing forms of multiple sclerosis. The medication is given as an intravenous infusion, which means it is delivered into a vein. The usual schedule is one dose every four weeks.
These insights are based on 14,205 comments about Tysabri from MyMSTeam members.MyMSTeam members who use Tysabri often say the most helpful strategies are staying on top of monitoring, planning around infusion days, and keeping your care team updated about side effects or changes. Many also mention that results can take time, and that practical support for scheduling, insurance, or infusion access can make treatment easier to stick with.
Get regular JC virus tests, MRI scans, and follow-up labs.
“They have to test you to see if you’re positive for the JC virus first, for that gives a higher potential for progressive multifocal leukoencephalopathy (PML).”
Keep track of side effects, and tell your doctor about reactions.
“Yesterday, I had my first infusion of Tysabri. I had a mild reaction to the medication. I started to have an itchy throat, and they gave me Benadryl.”
Ask about practical help for IV access.
“After four failed attempts to access a vein, the doctor recommended that I get an IV port. It was a scary thought at first, but I’m glad I did it.”
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In clinical studies of adults with relapsing forms of multiple sclerosis, the most common side effects of Tysabri affected 11 percent to 38 percent of people. These side effects were:
Tysabri can cause serious side effects that require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
Biogen, the manufacturer of Tysabri, offers the Biogen Copay Program and Infusion Copay Assistance Program. Eligible people with commercial insurance may pay as little as $0. If you have government insurance or no insurance, the website offers information on other ways to save on your prescription.
Biogen also offers help from Biogen Support Coordinators, who can explain coverage options and costs, guide you through the prior authorization process, and help identify financial assistance options. To learn more, visit the Tysabri website or call 800-456-2255.
Before starting Tysabri, your doctor may order a brain MRI scan.
Tell your doctor if you have any allergies to natalizumab or any ingredients in Tysabri.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Also, tell your doctor if you take medicines or have conditions that weaken your immune system.
Let your doctor know if you have had recent infections or nervous system problems in the past.
Do not take Tysabri if you have or have had progressive multifocal leukoencephalopathy, or if you have had a serious allergic reaction to natalizumab or any of its ingredients.
If you are pregnant, planning to become pregnant, or breastfeeding while taking Tysabri, talk with your doctor about the risks and benefits of treatment.
These answers are fact-checked by our editorial staff.
How effective is Tysabri?
In a two-year study on people with multiple sclerosis, 17 percent of people taking Tysabri had an increase in disability that lasted at least 12 weeks, compared with 29 percent of people taking placebo (an inactive treatment). The annual relapse rate was also lower with Tysabri. In that study, 67 percent of people taking Tysabri had no relapses, compared with 41 percent taking placebo. MRI scan results also favored Tysabri over placebo.
How often is Tysabri taken for multiple sclerosis?
For multiple sclerosis, Tysabri is given as an intravenous infusion over about one hour every four weeks.
What tests or monitoring are needed before and during Tysabri treatment for multiple sclerosis?
A brain MRI scan may be done before starting Tysabri. Doctors should watch for any new signs or symptoms that may suggest progressive multifocal leukoencephalopathy. People who test negative for anti-JCV antibodies should be tested again from time to time because results can change. Follow-up with a doctor is required three months after the first infusion, six months after the first infusion, every six months after that, and for at least six months after treatment stops.
What are the most important infection risks with Tysabri for multiple sclerosis?
Tysabri increases the risk of progressive multifocal leukoencephalopathy, a rare brain infection that usually leads to death or severe disability. Risk is higher in people who are anti-JCV antibody positive, have used Tysabri for more than two years, or used certain immunosuppressants before starting treatment. Tysabri can also increase the risk of other infections, including herpes infections of the brain, spinal cord lining, or eyes. People should report new or worsening symptoms that last several days during treatment and for about six months after stopping Tysabri.
On MyMSTeam, people share their experiences with multiple sclerosis, get advice, and find support from others who understand.
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