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Menopause May Speed Up Nerve Damage in MS

Written by Ted Samson
Posted on March 12, 2025

Results of a new study suggest that menopause could speed up progression of multiple sclerosis (MS). Researchers found that after menopause, women with MS showed a faster decline in neurological (brain and nerve) function and an increase in markers of nerve damage.

The study analyzed data from 184 postmenopausal women with MS who were followed for a median of 13 years. Using the Multiple Sclerosis Functional Composite assessment, researchers found declines in:

  • Walking speed
  • Fine-motor skills (hand dexterity)
  • Cognitive abilities, including information processing and working memory

Additionally, through blood tests, researchers observed an increase in levels of serum neurofilament light chain, a biomarker that indicates nerve damage.

Discuss Menopause With Your Doctor

Hormonal changes during menopause may impact the nervous system’s ability to repair itself, contributing to worsening MS symptoms. While more research is needed, these findings suggest that people with MS approaching menopause may want to discuss symptom management and treatment strategies with their neurologist.

Here are seven facts you should know about MS and menopause.

Find Your Team

On MyMSTeam, the social network for people living with multiple sclerosis and their loved ones, members come together to ask questions, give advice, and share their stories with others who understand life with MS.

Have you noticed changes in your MS symptoms around menopause? What strategies have helped you manage them? Share your experiences in a comment below, start a conversation on your Activities page, or connect with like-minded members in Groups.

Ted Samson is a content innovation editor at MyHealthTeam. Learn more about him here.
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