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MS and Tendonitis: The Connection and Tips for Relief

Medically reviewed by Chiara Rocchi, M.D.
Updated on September 17, 2024

Multiple sclerosis (MS) can trigger a variety of symptoms, including musculoskeletal pain that affects both muscles and joints. On MyMSTeam, the social network for people with MS, members often discuss tendonitis in different parts of their bodies.

One member asked, “Did anyone else randomly develop ‘tennis elbow’ because of MS?” Another wondered, “Has anyone experienced plantar fasciitis and MS?” Others share their common experiences with tendon pain, including neck, back, elbow, shoulder, hip, knee, and foot pain.

Learning about tendonitis (sometimes spelled “tendinitis”) can help you better understand what may be causing your pain and how to manage it.

What Are Tendons?

Tendons are strong, ropelike tissues made of fibers that connect muscle to bone. Many tendons attach to bone near the joints. Muscles, tendons, and ligaments (which connect bones to each other) work together like a support system for joints, keeping them stable while allowing movement.

What Is Tendonitis?

Tendonitis is a type of tendinopathy, an umbrella term to describe different types of tendon injury and inflammation. Tendinopathies include:

  • Tendonitis — Inflammation of tendons
  • Tenosynovitis — Inflammation of the sheath that surrounds tendons
  • Tendinosis — Tendon injury due to repetitive use

Conditions that affect muscles, tendons, or ligaments can weaken normal joint movement, cause pain, and lead to injury. If left untreated, some tendon injuries can progress to more severe problems such as ruptured (torn) tendons.

Symptoms of Tendinopathy

Common symptoms of tendinopathy include:

  • Pain
  • Burning
  • Tenderness
  • Swelling
  • Weakness
  • Stiffness
  • Limited range of motion

Tendinopathies can develop almost anywhere in the body but tend to affect joints, including the wrists, elbows, shoulders, knees, and ankles. Other sites of tendinopathy include the heels, bottom of the foot, fingers, neck, and back.

How long does tendonitis last? Pain caused by tendinopathy may be constant, or it may come and go. Pain may occur during activity, at rest, or both. Depending on the joints and tendons involved, pain may make it difficult to sit, stand, walk, grip, or bend joints.

Types of Tendinopathy

Common forms of tendinopathies include:

  • Tennis elbow or computer elbow — Involves the outer elbow
  • Golfer’s elbow — Affects the inner elbow
  • Rotator cuff tendonitis — Targets the top of the shoulder
  • Achilles tendonitis — Causes pain on the back of the ankle and heel
  • Plantar fasciitis — Pain in the heel as well as the arch and ball of the foot

MyMSTeam members have shared their struggles with tendinopathy. “The past several years I have also developed terrible pain,” shared one member. “It comes and goes, in both upper arms/shoulders as well as in one knee.”

Another shared, “I get pain in my back from sitting too long … and also in my elbows, shoulders, and knees.”

Another third agreed: “Same here, it’s like my shoulder hurts talking on the phone, or my elbow joints ache.”

How Is Tendinopathy Diagnosed?

Diagnosis of tendinopathy involves a medical history, physical exam, and sometimes imaging studies. A history of injury or repetitive movement can point to tendinopathy as the likely diagnosis.

Ultrasound of the tendon can show inflammation. Additionally, X-rays can show if there are other causes of pain or bony changes due to tendinopathy. Magnetic resonance imaging (MRI) scans can also be used to see inflammation, tears, and ruptures in tendons with great detail.

If you’re experiencing neuropathic pain, your neurologist might help diagnose the issue. They can work with you to figure out the cause of the pain and recommend treatment options.

The Connection Between MS and Tendinopathy

Tendinopathy can be caused by injury, long-term overuse, and, rarely, certain medications. MS can cause or contribute to tendinopathy in several ways. In MS, the protective layer around nerves, known as the myelin sheath, gets damaged. This damage leads to small injuries, called lesions, in the brain and spinal cord, which are part of the central nervous system.

MS can affect walking and posture. Over time, abnormal movements can lead to tendinopathy. In rare cases, certain drugs can cause tendon damage, including some drugs used to treat MS. It’s important to remember, however, that having tendinopathy with MS does not necessarily mean that your symptoms are related to MS. Tendonitis can have many other causes besides those related to MS.

MS Pain

People with MS can experience two types of pain: neuropathic pain and musculoskeletal pain. Neuropathic pain is nerve pain from damaged nerve fibers caused by MS. Musculoskeletal pain is caused by tissue injury or damage, including damage to the muscles and joints.

Neuropathic pain can take on many forms — sharp, stabbing pain, burning, itching, pins and needles, and sensations that are difficult to describe. Musculoskeletal pain, on the other hand, can be sharp, dull, or achy and may be aggravated by movement. Pain may be temporary and short-lived, or it may become chronic pain. Musculoskeletal pain is usually limited to specific muscles or joints rather than entire limbs.

It can be hard to figure out the type of pain someone is experiencing with MS, making it difficult to diagnose. Some MyMSTeam members have been frustrated by this. One member wrote, “I’ve seen four doctors and received four different diagnoses. … One said plantar fasciitis, one tendonitis, one just inflammation, and one said it’s MS progression.”

Abnormal Gait and Posture

Muscle weakness, muscle spasms, fatigue, poor balance, and numbness or altered sensation are all common MS symptoms. These symptoms can lead to difficulty walking and poor posture. Muscle spasticity caused by MS can make joints stiff and inflexible, preventing normal movement. Loss of sensation or painful sensations caused by nerve damage can also affect walking. Additionally, loss of muscle tone due to reduced physical activity can cause joint problems in people with MS.

With MS, your body tries to make up for the impairment by moving differently and using additional muscles to try to stabilize joints. Over time, abnormal joint movement due to the effects of MS on gait (how you walk) and posture can result in joint and tendon injury and pain when walking or doing other normal daily activities.

Medication-Induced Tendinopathy

Several MyMSTeam members have asked if their musculoskeletal pain could be from medications for MS. It’s rare, but some medications can contribute to tendon injury. Few medications used to treat MS are associated with tendon injury, but some drugs that treat more common conditions can cause tendon injury. When an injury is related to medication, the Achilles tendon is most often the site affected.

Disease-modifying therapies for MS that can cause joint pain or tendon damage include:

  • Rituximab (Rituxan), a biologic used to treat MS and other autoimmune and autoinflammatory diseases, has been associated with tendon damage in rare cases.
  • Alemtuzumab (Lemtrada), another biologic, is known to cause pain, including joint and back pain, as a side effect. Pain with alemtuzumab can also be a symptom of more serious side effects, so always seek medical attention, especially if you’re having chest pain.
  • Interferon beta-1a and interferon beta-1b are known to cause joint pain as a side effect, but research has not shown any link to tendon injury specifically.
  • Glatiramer acetate (Copaxone and Brabio), a disease-modifying therapy, is associated with joint or back pain in more than 1 in 10 users.

Some drugs used to treat common comorbidities (separate health conditions at the same time) of MS, including high cholesterol and high blood pressure, are known to cause tendon injury. Research shows that statins (cholesterol-lowering medications) are linked to tendon damage. The blood pressure medications amlodipine and drugs known as renin-angiotensin II receptor blockers can also cause damage to the tendons.

Long-term oral steroid use (glucocorticoids or corticosteroids) can cause tendon injury, but this is more common with steroid injections given near tendons.

Other drugs have also been shown to cause tendon injury. These drugs treat a wide range of diseases that are not typically linked to MS but sometimes develop in people with MS. They include:

  • Certain antibiotics (fluoroquinolones, cephalosporins, azithromycin)
  • Isotretinoin, used for skin conditions
  • Antiretroviral medications used to treat HIV
  • Sitagliptin taken to control blood sugar in people with diabetes
  • Aromatase inhibitors prescribed for breast cancer

Talk to your health care team if you’re concerned that a medication you’re taking may be contributing to tendonitis.

Repetitive Stress Injuries

A very common cause of tendinopathy is repetitive movements. Tennis elbow is a repetitive stress injury involving the muscles and tendons of the forearm. The name is misleading because tennis elbow can be caused by many different activities, including using a computer mouse.

Excessive walking, running, or standing can also cause tendinopathy, such as tendonitis of the knee, Achilles tendonitis, and plantar fasciitis. Even playing video games can lead to repetitive stress injuries affecting the hands and wrists.

Osteoporosis and Tendinopathy

Osteoporosis (loss of bone density) is a comorbidity of MS that can contribute to tendinopathy. As bones become weaker from osteoporosis, it affects the attached tendons. Research from the Journal of Bone and Mineral Metabolism has found that people with osteoporosis have a higher risk of rotator cuff injuries.

Tips for Tendonitis Relief

Treatment options for tendinopathy begin with RICE: rest, ice, compression, and elevation. Avoiding activities that cause pain, applying ice to swollen areas, using a wrap or sleeve around the affected area, and keeping the affected body part elevated are the first steps in treating tendon pain and injury.

Further treatment for tendinopathy can include:

  • Keeping the joint still
  • Undergoing physical or occupational therapy
  • Taking medications to reduce inflammation
  • Applying heat
  • Getting surgery for tendonitis (in severe cases)

Depending on the location of the tendinopathy, a splint or brace may be used to temporarily prevent a joint from moving in ways that will prevent the injury from healing. Physical therapy and occupational therapy can help treat and prevent tendon injury as well as help with symptoms of MS.

Applying heat with a heating pad, hot water bottle, or warm compress can help relieve pain, relax stiff tendons and muscles, and increase blood flow to promote healing.

Prescription or over-the-counter nonsteroidal anti-inflammatory drugs, such as ibuprofen or naproxen, can be used for pain management. Corticosteroid injections can treat pain and inflammation due to tendinopathy, but there’s a very small risk that steroid injections given near an injured or painful tendon can cause tendon damage, including rupture.

Some people may try acupuncture or other complementary therapies. If you’re experiencing neuropathic pain, your doctor may recommend medications including gabapentin or antidepressants.

How Can Tendinopathy Be Prevented?

There are several ways you can help prevent tendon, muscle, and joint injuries due to MS. First, finding an effective treatment regimen for MS can help. The other way to help prevent tendinopathy with MS is by safely exercising, including stretching.

Exercising

Exercise has many benefits for MS, including strengthening muscles and joints. Warming up before exercise, by doing light exercise for five minutes, can reduce the chance of injury. Yoga and tai chi are great ways to get exercise with MS. Adaptive yoga and tai chi can be adjusted to fit your physical abilities.

Stretching

Stretching, either alone or with other exercises, can greatly improve tendon health. You can stretch alone or with someone to help you. Regardless of how mild or severe your MS is, there are exercises and stretches that you can safely perform to improve your overall health, not just your joints and muscles.

Taking Breaks During Activities

If there’s a physical activity you’re doing for hours at a time, such as a long hike or playing video games, take breaks. These breaks will allow your joints to rest and help prevent tendonitis from developing.

Splinting

If you’re getting back into an activity you love after tendonitis has healed, consider wearing a splint on the affected joint to help prevent tendonitis from recurring. You can ask your doctor about what type of splint would be most effective. Splints for various joints are usually sold at pharmacies.

Talk With Your Doctor

Tendonitis and other tendon-related injuries can develop in people with MS due to abnormal movement, repetitive stress, or certain medications. Recognizing the symptoms and working with your health care team for an accurate diagnosis is important. Treatment often involves rest, physical therapy, and medication, while prevention strategies include exercise, stretching, and taking breaks during activities. Managing MS symptoms and caring for your tendons can help reduce pain and improve overall quality of life.

Find Your Team

On MyMSTeam, the social network for people with MS and their loved ones, more than 215,000 members come together to ask questions, give advice, and share their stories with others who understand life with MS.

Have you had joint pain or tendonitis with MS? Share your experience in the comments below, or start a conversation by posting on your Activities page.

References
  1. Multiple Sclerosis — Mayo Clinic
  2. A Survey of Severity and Distribution of Musculoskeletal Pain in Multiple Sclerosis Patients; A Cross-Sectional Study — The Archives of Bone and Joint Surgery
  3. Tendonitis and Tenosynovitis — University of Rochester Medical Center
  4. Tendinopathy and Tenosynovitis — Patient
  5. Tennis Elbow — Mayo Clinic
  6. Golfer’s Elbow — Mayo Clinic
  7. Rotator Cuff Injury — Mayo Clinic
  8. Achilles Tendinitis — Mayo Clinic
  9. Plantar Fasciitis — Mayo Clinic
  10. Ultrasound — Mayo Clinic
  11. X-Rays — Johns Hopkins Medicine
  12. Magnetic Resonance Imaging (MRI) — Johns Hopkins Medicine
  13. Tendonitis — Cleveland Clinic
  14. Pain and Itching — National Multiple Sclerosis Society
  15. Common Overuse Tendon Problems: A Review and Recommendations for Treatment — American Family Physician
  16. Tendinopathies in Video Gaming and Esports — Frontiers in Sports and Active Living
  17. Muscle Weakness and Loss of Movement Due to Multiple Sclerosis — National Multiple Sclerosis Society
  18. Spasticity and Multiple Sclerosis — National Multiple Sclerosis Society
  19. Walking (Gait) Difficulties — National Multiple Sclerosis Society
  20. Osteoporosis — Mayo Clinic
  21. Multiple Sclerosis Is Associated With Low Bone Mineral Density and Osteoporosis — Neurology: Clinical Practice
  22. Osteoporosis Increases the Risk of Rotator Cuff Tears: A Population-Based Cohort Study — Journal of Bone and Mineral Metabolism
  23. Mini-Review: Toxic Tendinopathy — Toxicologic Pathology
  24. Alemtuzumab Injection (Multiple Sclerosis) — MedlinePlus
  25. Interferon Beta-1a (Intramuscular Route, Subcutaneous Route) — Mayo Clinic
  26. Interferon Beta-1b (Subcutaneous Route) — Mayo Clinic
  27. Glatiramer Acetate (Copaxone and Brabio) — MS Society
  28. Comorbidity in US Patients With Multiple Sclerosis — Patient Related Outcome Measures
  29. Cephalexin-Associated Achilles Tendonitis: Case Report and Review of Drug-Induced Tendinopathy — Cureus
  30. Tendonitis/Tendinitis — Hospital for Special Surgery
  31. Exercising With Multiple Sclerosis — National Multiple Sclerosis Society
  32. Aerobic Exercise: How To Warm Up and Cool Down — Mayo Clinic
  33. Yoga and Multiple Sclerosis — National Multiple Sclerosis Society
  34. Adaptive Tai Chi — National Multiple Sclerosis Society
  35. Stretching Exercises — Multiple Sclerosis Trust

Chiara Rocchi, M.D. completed medical school and neurology residency at Polytechnic Marche University in Italy. Learn more about her here.
Kristopher Bunting, M.D. studied chemistry and life sciences at the U.S. Military Academy, West Point, and received his doctor of medicine degree from Tulane University. Learn more about him here.

A MyMSTeam Member

I
Had my tendons repaired due to trigger finger but in my thumb. Now they say I have a partially torn tendon behind my left knee. So yea my MS is causing every day Pain😢in my spine and my sciatica… read more

April 4, 2023
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